*연구과제명: Longitudinal Associations Between Gut Microbiome Diversity and Emotional Well-Being
-연구 기관: 서울대학교 행복연구센터, 서울대학교 심리학과, CJ 바이오사이언스 주식회사, 서울대학교 생명정보학 융합학과, 서울대학교 생물학과 (연구팀)
-저자: Sung-Ha Lee, Xyle Ku, Hyun-Seok Oh, Yeonjae Jung, Jongsik Chun, Incheol Choi
Objective: While a significant link between emotional well-being (EWB) and the gut microbiome has been reported recently, their temporal relationships remain elusive. This study aims to fill this gap by examining the longitudinal associations between EWB and the Shannon Index (SI), an indicator of gut microbiome diversity. Method: The analysis focusedon adataset that collectedparticipants’ current EWBand fecal sam- ples in both 2019 and 2022 (N = 57, 56.1% female, Mage = 52.47 years, SD = 12.65). Gut microbiome pro- files were generated by sequencing the 16S rRNA gene, from which SI was subsequently calculated. Results: The cross-lagged panel analysis revealed significant positive cross-sectional associations between EWB and SI in both 2019 (β = .296, SE = 0.121, p = .014) and 2022 (β = .324, SE = 0.119, p = .006). However, no significant longitudinal associations were found between 2019 EWB and 2022 SI (β = .068, SE = 0.138, p = .623), nor between 2019 SI and 2022 EWB (β =−.016, SE = 0.13, p = .899). Conclusions: Our findings indicate that emotional happiness may be associated with gut micro- biome profiles at a particular time point, but they may not serve as predictive factors foreach otherover time. Future research is needed to establish causal relationships between them.
*연구과제명: Longitudinal Associations Between Gut Microbiome Diversity and Emotional Well-Being
-연구 기관: 서울대학교 행복연구센터, 서울대학교 심리학과, CJ 바이오사이언스 주식회사, 서울대학교 생명정보학 융합학과, 서울대학교 생물학과 (연구팀)
-저자: Sung-Ha Lee, Xyle Ku, Hyun-Seok Oh, Yeonjae Jung, Jongsik Chun, Incheol Choi
Objective: While a significant link between emotional well-being (EWB) and the gut microbiome has been reported recently, their temporal relationships remain elusive. This study aims to fill this gap by examining the longitudinal associations between EWB and the Shannon Index (SI), an indicator of gut microbiome diversity. Method: The analysis focusedon adataset that collectedparticipants’ current EWBand fecal sam- ples in both 2019 and 2022 (N = 57, 56.1% female, Mage = 52.47 years, SD = 12.65). Gut microbiome pro- files were generated by sequencing the 16S rRNA gene, from which SI was subsequently calculated. Results: The cross-lagged panel analysis revealed significant positive cross-sectional associations between EWB and SI in both 2019 (β = .296, SE = 0.121, p = .014) and 2022 (β = .324, SE = 0.119, p = .006). However, no significant longitudinal associations were found between 2019 EWB and 2022 SI (β = .068, SE = 0.138, p = .623), nor between 2019 SI and 2022 EWB (β =−.016, SE = 0.13, p = .899). Conclusions: Our findings indicate that emotional happiness may be associated with gut micro- biome profiles at a particular time point, but they may not serve as predictive factors foreach otherover time. Future research is needed to establish causal relationships between them.