Emotional well-being and gut microbiome profiles by enterotype. Scientific reports, 10(1), 1-9.
Sung‑Ha Lee1, Seok‑HwanYoon2, Yeonjae Jung2, Namil Kim2, Uigi Min2, Jongsik Chun2,3* & Incheol Choi1,4*
With increasing attention being paid to improving emotional well-being, recent evidence points to gut microbiota as a key player in regulating mental and physical health via bidirectional communication between the brain and gut. Here, we examine the association between emotional well-being and gut microbiome profles (i.e., gut microbiome composition, diversity, and the moderating role of the enterotypes) among healthy Korean adults (n= 83, mean age = 48.9, SD= 13.2). The research was performed using high-throughput 16S rRNA gene sequencing to obtain gut microbiome profles, as well as a self-report survey that included the Positive Afect Negative Afect Schedule (PANAS). The cluster-based analysis identifed two enterotypes dominated by the genera Bacteroides (n= 49) and Prevotella (n= 34). Generalized linear regression analysis reveals signifcant associations between positive emotion and gut microbiome diversity (Shannon Index) among participants in the Prevotelladominant group, whereas no such relationship emerged among participants in the Bacteroides group. Moreover, a novel genus from the family Lachnospiraceae is associated with emotional well-being scores, both positive and negative. Together, the current fndings highlight the enterotype-specifc links between the gut microbiota community and emotion in healthy adults and suggest the possible roles of the gut microbiome in promoting mental health.
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Emotional well-being and gut microbiome profiles by enterotype. Scientific reports, 10(1), 1-9.
Sung‑Ha Lee1, Seok‑HwanYoon2, Yeonjae Jung2, Namil Kim2, Uigi Min2, Jongsik Chun2,3* & Incheol Choi1,4*
With increasing attention being paid to improving emotional well-being, recent evidence points to gut microbiota as a key player in regulating mental and physical health via bidirectional communication between the brain and gut. Here, we examine the association between emotional well-being and gut microbiome profles (i.e., gut microbiome composition, diversity, and the moderating role of the enterotypes) among healthy Korean adults (n= 83, mean age = 48.9, SD= 13.2). The research was performed using high-throughput 16S rRNA gene sequencing to obtain gut microbiome profles, as well as a self-report survey that included the Positive Afect Negative Afect Schedule (PANAS). The cluster-based analysis identifed two enterotypes dominated by the genera Bacteroides (n= 49) and Prevotella (n= 34). Generalized linear regression analysis reveals signifcant associations between positive emotion and gut microbiome diversity (Shannon Index) among participants in the Prevotelladominant group, whereas no such relationship emerged among participants in the Bacteroides group. Moreover, a novel genus from the family Lachnospiraceae is associated with emotional well-being scores, both positive and negative. Together, the current fndings highlight the enterotype-specifc links between the gut microbiota community and emotion in healthy adults and suggest the possible roles of the gut microbiome in promoting mental health.
*저작권 안내
DBpia에서 제공되는 모든 저작물의 저작권은 원저작자에게 있으며, 누리미디어는 각 저작물의 내용을 보증하거나 책임을 지지 않습니다. 그리고 DBpia에서 제공되는 저작물은 DBpia와 구독계약을 체결한 기관소속 이용자 혹은 해당 저작물의 개별 구매자가 비영리적으로만 이용할 수 있습니다. 그러므로 이에 위반하여 DBpia에서 제공되는 저작물을 복제, 전송 등의 방법으로 무단 이용하는 경우 관련 법령에 따라 민, 형사상의 책임을 질 수 있습니다.
*Copyright Information
Copyright of all literary works provided by DBpia belongs to the copyright holder(s)and Nurimedia does not guarantee contents of the literary work or assume responsibility for the same. In addition, the literary works provided by DBpia may only be used by the users affiliated to the institutions which executed a subscription agreement with DBpia or the individual purchasers of the literary work(s)for non-commercial purposes. Therefore, any person who illegally uses the literary works provided by DBpia by means of reproduction or transmission shall assume civil and criminal responsibility according to applicable laws and regulations.